Began her stage career in 1956 with the Georgian Polytechnic Institute’s popular music orchestra.
Laureate of the Sixth World Festival of Youth and Students (1957) in Moscow, where she performed the song “I Extinguished the Candle,” composed by Guram Bzvanelli to lyrics by Ioseb Grishashvili.
She was a soloist with the Georgian State Popular Music Orchestra “Rero.”
From 1964, she performed with the vocal-instrumental ensemble “Orera.”
From 1980, she began giving solo concerts.
She was awarded the Order of Honor for her outstanding contribution to the development of Georgian popular vocal music.
Stars bearing Nani Bregvadze’s name have been unveiled in Tbilisi, Moscow, and Baku.